TIME

When you experience strange pains, mysterious digestive issues, or other unexplained symptoms, you’d hope a trip to the doctor would solve your health woes. But sometimes, doctors have just as much trouble identifying certain disorders and conditions as their patients. “A lot of symptoms are nonspecific and variable, depending on the person,” says David Fleming, MD, president of the American College of Physicians and a professor of medicine at the University of Missouri. “On top of that, many diagnostic tests are expensive and aren’t done routinely, and even then they don’t always give us a black and white answer.” The following 5 conditions are notoriously difficult to pin down.

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Irritable bowel syndrome

Some conditions are difficult to diagnose because there is no real test to prove their existence; rather, they require a “diagnosis of elimination,” says Dr. Fleming, as doctors rule out all other…

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